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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T1046 Mexiletine hydrochloride

KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律

AhR; Sodium Channel Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂,是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流,从而降低心脏动作电位(0相)上升速率,并且降低浦肯野纤维的自律性而发挥抗心律失常作用。
T32030 GYKI-16638 HCl

GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638

GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h
T12023 Mexiletine-d6 hydrochloride

KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride

Others Others
Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.
T21427 Mexiletine

Mexitil,Mexiletene,KO-1173,KO1173,KO 1173

Mexiletine is a non-selective voltage-gated sodium channel blocker. It is a medicine in the class of IB anti-arrhythmic. Mexiletine may also be used in patients experiencing refractory pain and is effective to treat muscle stiffness resulting from myotonic dystrophy or non-dystrophic myotonias.

化合物

Mexiletine hydrochloride
Cat.No: T1046
Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律
Target: AhR, Sodium Channel
GYKI-16638 HCl
Cat.No: T32030
Synonym: GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638
Target:
Mexiletine-d6 hydrochloride
Cat.No: T12023
Synonym: KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride
Target: Others
Mexiletine
Cat.No: T21427
Synonym: Mexitil,Mexiletene,KO-1173,KO1173,KO 1173
Target:
Cat. No. Product Name Target Signaling Pathways
T1879 3-Methyladenine

3-MA,3-甲基腺嘌呤,NSC 66389

Mitophagy; PI3K; Endogenous Metabolite; Autophagy Autophagy; Metabolism; PI3K/Akt/mTOR signaling
3-Methyladenine (3-MA) 是一种 PI3K 抑制剂,选择性抑制 IB 类 PI3Kγ (IC50=60 μM) 和 III 类 VPS34 (IC50=25 μM)。3-Methyladenine 具有自噬抑制活性。

天然产物

3-Methyladenine
Cat.No: T1879
Synonym: 3-MA,3-甲基腺嘌呤,NSC 66389
Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy
TargetMol Loading
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