4
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1046 |
Mexiletine hydrochloride
KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律 |
AhR; Sodium Channel | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism |
Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂,是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流,从而降低心脏动作电位(0相)上升速率,并且降低浦肯野纤维的自律性而发挥抗心律失常作用。 | |||
T32030 |
GYKI-16638 HCl
GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638 |
||
GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h | |||
T12023 |
Mexiletine-d6 hydrochloride
KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride |
Others | Others |
Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic. | |||
T21427 |
Mexiletine
Mexitil,Mexiletene,KO-1173,KO1173,KO 1173 |
||
Mexiletine is a non-selective voltage-gated sodium channel blocker. It is a medicine in the class of IB anti-arrhythmic. Mexiletine may also be used in patients experiencing refractory pain and is effective to treat muscle stiffness resulting from myotonic dystrophy or non-dystrophic myotonias. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1879 |
3-Methyladenine
3-MA,3-甲基腺嘌呤,NSC 66389 |
Mitophagy; PI3K; Endogenous Metabolite; Autophagy | Autophagy; Metabolism; PI3K/Akt/mTOR signaling |
3-Methyladenine (3-MA) 是一种 PI3K 抑制剂,选择性抑制 IB 类 PI3Kγ (IC50=60 μM) 和 III 类 VPS34 (IC50=25 μM)。3-Methyladenine 具有自噬抑制活性。 |